{"id":4962,"date":"2022-02-21T20:05:59","date_gmt":"2022-02-21T20:05:59","guid":{"rendered":"https:\/\/www.echelecabeza.com\/?p=4962"},"modified":"2025-05-13T01:54:03","modified_gmt":"2025-05-13T01:54:03","slug":"componentes-del-tusibi-en-2021","status":"publish","type":"post","link":"https:\/\/www.echelecabeza.com\/componentes-del-tusibi-en-2021\/","title":{"rendered":"Componentes del Tusibi en 2021. Alerta!"},"content":{"rendered":"<p><strong>AN\u00c1LISIS POR TLC A MUESTRAS DE <em>TUSI<\/em> EVENTOS JULIO Y AGOSTO 2021<\/strong><\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p style=\"text-align: right;\"><strong>Elaborado por:<\/strong> Mauro Adri\u00e1n D\u00edaz Moreno, MSc.<\/p>\n<p style=\"text-align: right;\">Director T\u00e9cnico del Servicio de An\u00e1lisis de Sustancias Proyecto \u00c9chele Cabeza<\/p>\n<p style=\"text-align: right;\">Corporaci\u00f3n Acci\u00f3n T\u00e9cnica Social<\/p>\n<p>&nbsp;<\/p>\n<p>\u00c9chele Cabeza es un proyecto de la Corporaci\u00f3n Acci\u00f3n T\u00e9cnica Social que est\u00e1 enfocado en la reducci\u00f3n de riesgos y da\u00f1os (RRD) asociados al uso de sustancias psicoactivas (SPA). Como principio b\u00e1sico de este enfoque se acepta que el consumo de drogas es un fen\u00f3meno que existe, no se debe prohibir, no se debe estigmatizar y se debe atender desde la salud p\u00fablica y los derechos humanos. Debido a esto \u00c9chele Cabeza se encarga de divulgar informaci\u00f3n basada en evidencia a las personas mayores de edad que hayan decidido consumir, con el objetivo de prevenir riesgos espec\u00edficos, promover h\u00e1bitos de auto cuidado y gestionar del placer. Dentro de las estrategias de RRD se encuentra el servicio an\u00e1lisis de sustancias (SAS), con el cual se generan alertas tempranas asociadas a la presencia de adulterantes, suplantadores, sustancias de corte y alta concentraci\u00f3n de las SPA. En el presente documento se reportan los resultados de la cromatograf\u00eda de capa delgada (TLC) de diferentes muestras de <em>tusi<\/em> recolectadas en la primera etapa de la reactivaci\u00f3n econ\u00f3mica del 2021, el cual se observa que este c\u00f3ctel de sustancias tiene como sustancia esencial a la ketamina.<\/p>\n<ol>\n<li><strong> OBJETIVO<\/strong><\/li>\n<\/ol>\n<p>Caracterizar de forma cualitativa por medio de la t\u00e9cnica de cromatograf\u00eda de capa delgada (TLC) diferentes muestras de &#8220;<em>tusi&#8221;\u00a0<\/em>recolectadas en los eventos BlackBox\/T78 (17 de julio) , BlackBox\/Hernan Cattaneo (24 de julio), Exxxile\/Raffaele Atanasio (31 de julio), Festival Alba (31 de julio) y Sensor II Aniversario (21 de agosto).<\/p>\n<ol start=\"2\">\n<li><strong> M\u00c9TODOS<\/strong><\/li>\n<\/ol>\n<p><strong>\u00a02.1 Muestras<\/strong><\/p>\n<p>Se defini\u00f3 un grupo conformado por 22 muestras (tabla 1). Estas muestras fueron entregadas an\u00f3nimamente durante el servicio de an\u00e1lisis de sustancias (SAS) en las intervenciones de los eventos mencionados. Cada muestra se identifica con la letra F y el n\u00famero consecutivo de la muestra en el evento (tabla 2). Todas las muestras del presente estudio fueron negativas para 2C-B. Este resultado fue entregado inmediatamente a la persona due\u00f1a de la muestra durante el evento, y junto a esto se dio informaci\u00f3n sobre reducci\u00f3n de riesgo y da\u00f1o en la que se incluyeron dosificaci\u00f3n, efectos, riesgos de uso e interacciones con otras sustancias.<\/p>\n<p style=\"text-align: left;\"><strong>Tabla 1.<\/strong> N\u00famero de muestras por evento<\/p>\n<table class=\" alignleft\" width=\"363\">\n<tbody>\n<tr>\n<td width=\"170\"><strong>Evento<\/strong><\/td>\n<td width=\"193\"><strong>Cantidad de muestras<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"170\">T78<\/td>\n<td width=\"193\">5<\/td>\n<\/tr>\n<tr>\n<td width=\"170\">Hernan Cattaneo<\/td>\n<td width=\"193\">5<\/td>\n<\/tr>\n<tr>\n<td width=\"170\">Raffaele Attanasio<\/td>\n<td width=\"193\">5<\/td>\n<\/tr>\n<tr>\n<td width=\"170\">Festival Alba<\/td>\n<td width=\"193\">3<\/td>\n<\/tr>\n<tr>\n<td width=\"170\">Sensor II Aniversario<\/td>\n<td width=\"193\">4<\/td>\n<\/tr>\n<tr>\n<td width=\"170\"><strong>TOTAL<\/strong><\/td>\n<td width=\"193\">22<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: left;\"><strong>\u00a0<\/strong><strong>2.2 T\u00e9cnicas de an\u00e1lisis utilizadas<\/strong><strong>\u00a0<\/strong><\/p>\n<p style=\"text-align: left;\"><strong>Pruebas preliminares colorim\u00e9tricas<\/strong><\/p>\n<p>Estas pruebas permiten conocer la presencia o ausencia de determinadas sustancias gracias a la coloraci\u00f3n obtenida despu\u00e9s de la reacci\u00f3n entre los reactivos de cada prueba y la muestra.<\/p>\n<p><strong>Identificaci\u00f3n de los componentes por TLC<\/strong><\/p>\n<p>La TLC se fundamenta como la separaci\u00f3n selectiva de las sustancias que componen una mezcla. Esta t\u00e9cnica no solo sirve como criterio de pureza de sustancias, sino tambi\u00e9n para la identificaci\u00f3n cualitativa de los componentes de una mezcla y para llevar el control de reacciones y separaciones al purificar productos de reacciones. En la TLC la fase estacionaria es una capa delgada de un adsorbente que est\u00e1 sobre una placa de aluminio.<\/p>\n<p>El procedimiento consiste en que una peque\u00f1a cantidad de la muestra es sembrada en la parte inferior de la placa, y esta placa es colocada en un recipiente que contiene una cantidad de un solvente que sirve como fase m\u00f3vil. La distancia en la cual el solvente mueve los compuestos en la placa es dependiente de la habilidad de los compuestos de retenerse al adsorbente de la placa. De acuerdo con ello, los desplazamientos de los componentes de la muestra con patrones puros se comparan por medio de un revelado con luz ultravioleta. Los patrones utilizados para este estudio fueron 2C-B, ketamina, MDMA, cafe\u00edna y oxicodona.<\/p>\n<ol start=\"3\">\n<li><strong> RESULTADOS DE LA CARACTERIZACI\u00d3N CUALITATIVA<\/strong><\/li>\n<\/ol>\n<p style=\"text-align: left;\"><strong>Tabla 2. <\/strong>Resultados de TLC<\/p>\n<table class=\" alignleft\" style=\"height: 703px;\" width=\"699\">\n<tbody>\n<tr>\n<td width=\"88\"><strong>Evento<\/strong><\/td>\n<td width=\"66\">\n<p style=\"text-align: center;\"><strong>Muestra<\/strong><\/p>\n<\/td>\n<td width=\"46\"><strong>2C-B<\/strong><\/td>\n<td width=\"74\"><strong>Ketamina<\/strong><\/td>\n<td width=\"56\"><strong>MDMA<\/strong><\/td>\n<td width=\"63\"><strong>Cafe\u00edna<\/strong><\/td>\n<td width=\"83\"><strong>Oxicodona<\/strong><\/td>\n<td width=\"97\"><strong>Desconocida 1<\/strong><\/td>\n<td width=\"97\"><strong>Desconocida 2<\/strong><\/td>\n<\/tr>\n<tr>\n<td rowspan=\"5\" width=\"88\"><strong>T78<\/strong><\/td>\n<td width=\"66\">F07<\/td>\n<td width=\"46\">&#8211;<\/td>\n<td width=\"74\">+<\/td>\n<td width=\"56\">+<\/td>\n<td width=\"63\">&#8211;<\/td>\n<td width=\"83\">&#8211;<\/td>\n<td width=\"97\">+<\/td>\n<td width=\"97\">+<\/td>\n<\/tr>\n<tr>\n<td width=\"66\">F08<\/td>\n<td width=\"46\">&#8211;<\/td>\n<td width=\"74\">+<\/td>\n<td width=\"56\">+<\/td>\n<td width=\"63\">+<\/td>\n<td width=\"83\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<td width=\"97\">+<\/td>\n<\/tr>\n<tr>\n<td width=\"66\">F17<\/td>\n<td width=\"46\">&#8211;<\/td>\n<td width=\"74\">+<\/td>\n<td width=\"56\">+<\/td>\n<td width=\"63\">+<\/td>\n<td width=\"83\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<\/tr>\n<tr>\n<td width=\"66\">F26<\/td>\n<td width=\"46\">&#8211;<\/td>\n<td width=\"74\">+<\/td>\n<td width=\"56\">+<\/td>\n<td width=\"63\">&#8211;<\/td>\n<td width=\"83\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<\/tr>\n<tr>\n<td width=\"66\">F44<\/td>\n<td width=\"46\">&#8211;<\/td>\n<td width=\"74\">+<\/td>\n<td width=\"56\">+<\/td>\n<td width=\"63\">+<\/td>\n<td width=\"83\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"5\" width=\"88\"><strong>Hernan Cattaneo<\/strong><\/td>\n<td width=\"66\">F04<\/td>\n<td width=\"46\">&#8211;<\/td>\n<td width=\"74\">+<\/td>\n<td width=\"56\">&#8211;<\/td>\n<td width=\"63\">&#8211;<\/td>\n<td width=\"83\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<td width=\"97\">+<\/td>\n<\/tr>\n<tr>\n<td width=\"66\">F06<\/td>\n<td width=\"46\">&#8211;<\/td>\n<td width=\"74\">+<\/td>\n<td width=\"56\">+<\/td>\n<td width=\"63\">&#8211;<\/td>\n<td width=\"83\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<\/tr>\n<tr>\n<td width=\"66\">F25<\/td>\n<td width=\"46\">&#8211;<\/td>\n<td width=\"74\">+<\/td>\n<td width=\"56\">+<\/td>\n<td width=\"63\">&#8211;<\/td>\n<td width=\"83\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<td width=\"97\">+<\/td>\n<\/tr>\n<tr>\n<td width=\"66\">F31<\/td>\n<td width=\"46\">&#8211;<\/td>\n<td width=\"74\">+<\/td>\n<td width=\"56\">+<\/td>\n<td width=\"63\">+<\/td>\n<td width=\"83\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<\/tr>\n<tr>\n<td width=\"66\">F32<\/td>\n<td width=\"46\">&#8211;<\/td>\n<td width=\"74\">+<\/td>\n<td width=\"56\">+<\/td>\n<td width=\"63\">&#8211;<\/td>\n<td width=\"83\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"5\" width=\"88\"><strong>Raffaele Attanasio<\/strong><\/td>\n<td width=\"66\">F16<\/td>\n<td width=\"46\">&#8211;<\/td>\n<td width=\"74\">+<\/td>\n<td width=\"56\">+<\/td>\n<td width=\"63\">&#8211;<\/td>\n<td width=\"83\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<\/tr>\n<tr>\n<td width=\"66\">F20<\/td>\n<td width=\"46\">&#8211;<\/td>\n<td width=\"74\">+<\/td>\n<td width=\"56\">+<\/td>\n<td width=\"63\">&#8211;<\/td>\n<td width=\"83\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<\/tr>\n<tr>\n<td width=\"66\">F29<\/td>\n<td width=\"46\">&#8211;<\/td>\n<td width=\"74\">+<\/td>\n<td width=\"56\">+<\/td>\n<td width=\"63\">&#8211;<\/td>\n<td width=\"83\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<\/tr>\n<tr>\n<td width=\"66\">F32<\/td>\n<td width=\"46\">&#8211;<\/td>\n<td width=\"74\">+<\/td>\n<td width=\"56\">&#8211;<\/td>\n<td width=\"63\">+<\/td>\n<td width=\"83\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<td width=\"97\">+<\/td>\n<\/tr>\n<tr>\n<td width=\"66\">F35<\/td>\n<td width=\"46\">&#8211;<\/td>\n<td width=\"74\">+<\/td>\n<td width=\"56\">+<\/td>\n<td width=\"63\">&#8211;<\/td>\n<td width=\"83\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<td width=\"97\">+<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"4\" width=\"88\"><strong>Sensor II Aniversario<\/strong><\/td>\n<td width=\"66\">F30<\/td>\n<td width=\"46\">&#8211;<\/td>\n<td width=\"74\">+<\/td>\n<td width=\"56\">+<\/td>\n<td width=\"63\">&#8211;<\/td>\n<td width=\"83\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<\/tr>\n<tr>\n<td width=\"66\">F43<\/td>\n<td width=\"46\">&#8211;<\/td>\n<td width=\"74\">+<\/td>\n<td width=\"56\">+<\/td>\n<td width=\"63\">+<\/td>\n<td width=\"83\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<\/tr>\n<tr>\n<td width=\"66\">F45<\/td>\n<td width=\"46\">&#8211;<\/td>\n<td width=\"74\">+<\/td>\n<td width=\"56\">+<\/td>\n<td width=\"63\">&#8211;<\/td>\n<td width=\"83\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<\/tr>\n<tr>\n<td width=\"66\">F57<\/td>\n<td width=\"46\">&#8211;<\/td>\n<td width=\"74\">+<\/td>\n<td width=\"56\">&#8211;<\/td>\n<td width=\"63\">&#8211;<\/td>\n<td width=\"83\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"3\" width=\"88\"><strong>Festival Alba<\/strong><\/td>\n<td width=\"66\">F10<\/td>\n<td width=\"46\">&#8211;<\/td>\n<td width=\"74\">+<\/td>\n<td width=\"56\">+<\/td>\n<td width=\"63\">&#8211;<\/td>\n<td width=\"83\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<td width=\"97\">+<\/td>\n<\/tr>\n<tr>\n<td width=\"66\">F27<\/td>\n<td width=\"46\">&#8211;<\/td>\n<td width=\"74\">+<\/td>\n<td width=\"56\">+<\/td>\n<td width=\"63\">+<\/td>\n<td width=\"83\">&#8211;<\/td>\n<td width=\"97\">+<\/td>\n<td width=\"97\">&#8211;<\/td>\n<\/tr>\n<tr>\n<td width=\"66\">F32<\/td>\n<td width=\"46\">&#8211;<\/td>\n<td width=\"74\">+<\/td>\n<td width=\"56\">&#8211;<\/td>\n<td width=\"63\">+<\/td>\n<td width=\"83\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<td width=\"97\">&#8211;<\/td>\n<\/tr>\n<tr>\n<td width=\"88\"><strong>TOTAL<\/strong><\/td>\n<td width=\"66\">22<\/td>\n<td width=\"46\">0<\/td>\n<td width=\"74\">22<\/td>\n<td width=\"56\">18<\/td>\n<td width=\"63\">8<\/td>\n<td width=\"83\">0<\/td>\n<td width=\"97\">2<\/td>\n<td width=\"97\">7<strong>\u00a0<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>4. INTERPRETACI\u00d3N DE RESULTADOS<\/strong><\/p>\n<p><strong>\u00a0El color: sin mol\u00e9cula, pero con keta<\/strong><\/p>\n<p>Toda muestra que la persona usuaria ingresa como <em>tusi<\/em> o color es altamente probable que no tenga 2C-B y sea una mezcla de por lo menos colorante, saborizante y ketamina. Esto ha significado un reto para \u00c9chele Cabeza el abordaje tanto de la mezcla como a quienes la usan; tarea que requiere de constante actualizaci\u00f3n. Por esta raz\u00f3n, durante la \u00faltima d\u00e9cada se ha tratado aclarar la confusi\u00f3n dada por el nombre de ambas sustancias (al pronunciar 2C-B en ingl\u00e9s) y entender al <strong>polvo coloreado como un c\u00f3ctel de amplia comercializaci\u00f3n<\/strong> que cada a\u00f1o parece estar en auge.<\/p>\n<p>El resultado de cada muestra analizada se observa en la tabla 2. La totalidad de las muestras no contienen 2C-B pero s\u00ed contienen ketamina. La segunda sustancia encontrada con m\u00e1s frecuencia es MDMA, seguida por la cafe\u00edna. En el an\u00e1lisis de estas muestras no se encontr\u00f3 oxicodona y se encontr\u00f3 m\u00e1s de una sustancia desconocida. Es de resaltar que la identificaci\u00f3n de sustancias por medio de TLC est\u00e1 limitada por la comparaci\u00f3n de los componentes de la mezcla con patrones puros y por la concentraci\u00f3n de dichos componentes. Esto implica que se necesitan t\u00e9cnicas de an\u00e1lisis instrumentales que puedan identificar cu\u00e1ntas, cu\u00e1les y en qu\u00e9 cantidad est\u00e1n los componentes presentes en el <em>tusi<\/em> para poder crear estrategias completas de salud p\u00fablica.<\/p>\n<p><strong>Con el <em>tusi<\/em>, la keta por la nariz entra<\/strong><\/p>\n<p>Al igual que el m\u00e1s reciente reporte de Energy Control,<sup>1<\/sup> todas las muestras analizadas en el presente estudio contienen ketamina. Lo que es muy probable que una persona que usa<em> tusi<\/em> est\u00e1 usando ketamina indirectamente. Dado que es la administraci\u00f3n m\u00e1s com\u00fan de este polvo (generalmente rosado) es por v\u00eda nasal, se debe tener en cuenta que una dosis alta de ketamina es aquella superior a los 75 mg; cantidad que puede se puede alcanzar al esnifar varias veces el <em>tusi <\/em>en una sesi\u00f3n.<sup>2<\/sup> Situaci\u00f3n que es facilitada por la degustaci\u00f3n de fragancias o saborizantes agradables cuando el combinado transita por el tracto respiratorio superior y regi\u00f3n posterior de la lengua.<\/p>\n<p><strong>La ketamina <\/strong>(figura 1) es un agente anest\u00e9sico, analg\u00e9sico y sedante ampliamente utilizado en medicina humana y veterinaria. Una dosis media por v\u00eda nasal est\u00e1 entre los 30 a 75 mg,<sup>3<\/sup> y sus efectos pueden durar de los 45 a 60 minutos. Esta sustancia disminuye la conectividad entre las \u00e1reas corticales del cerebro que reciben informaci\u00f3n sensorial y \u00e1reas de asociaci\u00f3n, lo que da como resultado sensaciones alteradas del tiempo, el espacio, la conciencia corporal y puede dar lugar a alucinaciones v\u00edvidas.<\/p>\n<p><img decoding=\"async\" class=\"alignleft\" 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alt=\"\" title=\"\"><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: left;\"><strong>Figura 1.<\/strong> Ketamina<\/p>\n<p>La experiencia disociativa m\u00e1s intensa que ocurre con la ketamina se conoce como <strong><em>K-hole<\/em><\/strong>, la cual est\u00e1 caracterizada por experiencias extracorporales, alucinaciones, despersonalizaci\u00f3n y desrealizaci\u00f3n. Es fenomenol\u00f3gicamente similar a la psicosis catat\u00f3nica. Sin embargo, se cree que los individuos con predisposici\u00f3n a la psicosis tienen un mayor riesgo de alteraciones persistentes de la conciencia precipitadas por la ketamina. Por esto es importante que cada persona tome mayor conciencia del <em>set<\/em> individual (personalidad, preparaci\u00f3n, expectativa e intenci\u00f3n de la persona que tiene la experiencia) antes del uso del color.<sup>4<\/sup><\/p>\n<p><strong>La keta y sus compa\u00f1\u00edas<\/strong><\/p>\n<p>De acuerdo con la tabla 3 se resaltan las interacciones m\u00e1s comunes de este estudio, que ser\u00edan la ketamina con alcohol, con cafe\u00edna y con MDMA, lo que da a entender que el uso del <em>tusi <\/em>es un policonsumo <em>per se<\/em>.<\/p>\n<p style=\"text-align: left;\"><strong>Tabla 3. <\/strong>Resumen de resultados con respecto a las sustancias detectadas en 22 muestras<\/p>\n<table class=\" alignleft\" width=\"557\">\n<tbody>\n<tr>\n<td width=\"170\"><strong>Sustancia<\/strong><\/td>\n<td width=\"193\"><strong>N\u00famero de muestras<\/strong><\/td>\n<td width=\"193\"><strong>Porcentaje con respecto al total de muestras<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"170\">Ketamina<\/td>\n<td width=\"193\">22<\/td>\n<td width=\"193\">100%<\/td>\n<\/tr>\n<tr>\n<td width=\"170\">MDMA<\/td>\n<td width=\"193\">18<\/td>\n<td width=\"193\">82%<\/td>\n<\/tr>\n<tr>\n<td width=\"170\">Cafe\u00edna<\/td>\n<td width=\"193\">8<\/td>\n<td width=\"193\">36%<\/td>\n<\/tr>\n<tr>\n<td width=\"170\">Desconocida 2<\/td>\n<td width=\"193\">7<\/td>\n<td width=\"193\">32%<\/td>\n<\/tr>\n<tr>\n<td width=\"170\">Desconocida 1<\/td>\n<td width=\"193\">2<\/td>\n<td width=\"193\">9%<\/td>\n<\/tr>\n<tr>\n<td width=\"170\">Oxicodona<\/td>\n<td width=\"193\">0<\/td>\n<td width=\"193\">0%<\/td>\n<\/tr>\n<tr>\n<td width=\"170\">2C-B<\/td>\n<td width=\"193\">0<\/td>\n<td width=\"193\">0%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: left;\">Por el contexto de su uso, las personas usuarias deben tener en cuenta que <strong>la interacci\u00f3n entre alcohol y ketamina es altamente peligrosa. <\/strong>El alcohol es una sustancia depresora del sistema nervioso y la ketamina es un anest\u00e9sico disociativo. Su nivel de interacci\u00f3n depende de las cantidades consumidas y del metabolismo de cada persona. Sin embargo, es com\u00fan que su interacci\u00f3n est\u00e9 caracterizada por mareos, n\u00e1useas, v\u00f3mitos, confusi\u00f3n, excitaci\u00f3n, visi\u00f3n borrosa, dificultades para hablar o moverse, disminuci\u00f3n de la respuesta al dolor, aumento de la frecuencia card\u00edaca. <sup>5,6<\/sup><\/p>\n<p>En cuanto a la <strong>ketamina con MDMA (\u00e9xtasis)<\/strong>, ambas sustancias dentro de su mecanismo de acci\u00f3n tienden a generar mayor liberaci\u00f3n de neurotransmisores como la serotonina, lo cual puede aumentar la probabilidad del s\u00edndrome serotonin\u00e9rgico y \u201cgolpe de calor\u201d. Aunque el \u00e9xtasis tiene poca probabilidad de generar estados alucinatorios estructurados, en combinaci\u00f3n con la ketamina s\u00ed puede aumentar el riesgo de cuadros de psicosis toxica o episodios psic\u00f3ticos m\u00e1s prolongados.<sup>7<\/sup> Por otra parte, en un estudio se observ\u00f3 que la coadministraci\u00f3n de <strong>cafe\u00edna con ketamina<\/strong> produjo efectos aditivos sobre la hiperactividad locomotora, el aumento de la descoordinaci\u00f3n motora y la incidencia de muerte, pero no afect\u00f3 significativamente los d\u00e9ficits sensoriales motores y la anestesia inducida por ketamina.<sup>8<\/sup><\/p>\n<p>En cuanto a una advertencia general del <em>tusi<\/em>, es que, debido a la ilegalidad del mercado y ampl\u00edsima diversificaci\u00f3n de recetas se debe tener cuidado por la presunci\u00f3n de la introducci\u00f3n de medicamentos como opioides, benzodiacepinas y antidepresivos. Sustancias que no pueden ser detectadas en los an\u00e1lisis colorim\u00e9tricos preliminares realizados en los eventos del presente estudio. Por esta raz\u00f3n se mantienen las recomendaciones de reducci\u00f3n de riesgo y da\u00f1o tales como:<\/p>\n<ul>\n<li>Manejar la dosificaci\u00f3n tanto en cantidad como con amplios intervalos de tiempo entre inhaladas.<\/li>\n<li>Evitar consumirlo de forma oral porque los efectos son m\u00e1s duraderos e intensos al requerir m\u00e1s cantidad.<\/li>\n<li>Evitar el policonsumo adicional con alcohol, \u00e9xtasis, coca\u00edna y psicod\u00e9licos.<\/li>\n<li>Evaluar el <em>set<\/em> (personalidad, preparaci\u00f3n, expectativa e intenci\u00f3n) y el <em>setting<\/em> (entorno f\u00edsico, social y cultural)<\/li>\n<\/ul>\n<ol start=\"5\">\n<li><strong> CONCLUSIONES<\/strong><\/li>\n<\/ol>\n<p>La ketamina es la sustancia m\u00e1s frecuente en las muestras del presente estudio. Adicionalmente, todas las muestras presentaron m\u00e1s de una sustancia, lo que implica que el consumo de <em>tusi<\/em> viene con policonsumo incluido. Adem\u00e1s, por el contexto de su uso es probable que sea usada junto con la sustancia psicoactiva m\u00e1s consumida que es el alcohol. Por esto se advierte sobre los riesgos del uso de<em> tusi <\/em>considerando que dada las limitaciones de la t\u00e9cnica de TLC no fue posible detectar otras sustancias que pueden implicar riesgos adicionales como opioides, benzodiacepinas y antidepresivos.<\/p>\n<ol start=\"6\">\n<li><strong> REFERENCIAS<\/strong><\/li>\n<\/ol>\n<p>(1) \u00a0\u00a0\u00a0\u00a0\u00a0 Energy Control. Sustancias principales: Tusib\u00ed https:\/\/energycontrol.org\/sustancias\/tusibi\/.<\/p>\n<p>(2) \u00a0\u00a0\u00a0\u00a0\u00a0 Kalsi, S. S.; Wood, D. M.; Dargan, P. I. The Epidemiology and Patterns of Acute and Chronic Toxicity Associated with Recreational Ketamine Use. <em>Emerging Health Threats Journal<\/em> <strong>2011<\/strong>, <em>4<\/em> (1).<\/p>\n<p>(3) \u00a0\u00a0\u00a0\u00a0\u00a0 Energy Control. Sustancias principales: Ketamina https:\/\/energycontrol.org\/sustancias\/ketamina\/.<\/p>\n<p>(4) \u00a0\u00a0\u00a0\u00a0\u00a0 Hartogsohn, I. Constructing Drug Effects: A History of Set and Setting. <strong>2017<\/strong>.<\/p>\n<p>(5) \u00a0\u00a0\u00a0\u00a0\u00a0 Wolff, K.; Winstock, A. R. Ketamine From Medicine to Misuse. <em>CNS Drugs<\/em> <strong>2006<\/strong>, <em>20<\/em> (3), 199\u2013218.<\/p>\n<p>(6) \u00a0\u00a0\u00a0\u00a0\u00a0 Dillon, P.; Copeland, J.; Jansen, K. Patterns of Use and Harms Associated with Non-Medical Ketamine Use. <em>Drug and Alcohol Dependence<\/em> <strong>2003<\/strong>, <em>69<\/em> (1), 23\u201328.<\/p>\n<p>(7) \u00a0\u00a0\u00a0\u00a0\u00a0 \u00c9chele Cabeza. 2CB vs \u201cTusib\u00ed\u201d (Color o mal llamada coca\u00edna rosada) https:\/\/www.echelecabeza.com\/2cb-vs-tusibi-color-o-mal-llamada-cocaina-rosada\/.<\/p>\n<p>(8) \u00a0\u00a0\u00a0\u00a0\u00a0 Hsu, H. R.; Mei, Y. Y.; Wu, C. Y.; Chiu, P. H.; Chen, H. H. Behavioural and Toxic Interaction Profile of Ketamine in Combination with Caffeine. <em>Basic and Clinical Pharmacology and Toxicology<\/em> <strong>2009<\/strong>, <em>104<\/em> (5), 379\u2013383.[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>El Tusibi es una mezcla cada vez m\u00e1s incierta y peligrosa, aqu\u00ed nuestro m\u00e1s reciente an\u00e1lisis de sus componentes en el a\u00f1o 2021. <\/p>\n","protected":false},"author":3,"featured_media":5276,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[143],"class_list":["post-4962","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publicaciones","tag-alertas-psicoactivas"],"_links":{"self":[{"href":"https:\/\/www.echelecabeza.com\/wp-json\/wp\/v2\/posts\/4962","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.echelecabeza.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.echelecabeza.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.echelecabeza.com\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.echelecabeza.com\/wp-json\/wp\/v2\/comments?post=4962"}],"version-history":[{"count":2,"href":"https:\/\/www.echelecabeza.com\/wp-json\/wp\/v2\/posts\/4962\/revisions"}],"predecessor-version":[{"id":5696,"href":"https:\/\/www.echelecabeza.com\/wp-json\/wp\/v2\/posts\/4962\/revisions\/5696"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.echelecabeza.com\/wp-json\/wp\/v2\/media\/5276"}],"wp:attachment":[{"href":"https:\/\/www.echelecabeza.com\/wp-json\/wp\/v2\/media?parent=4962"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.echelecabeza.com\/wp-json\/wp\/v2\/categories?post=4962"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.echelecabeza.com\/wp-json\/wp\/v2\/tags?post=4962"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}